Rethinking Cancer
Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg and Mina J. Bissell
Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg and Mina J. Bissell
Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg and Mina J. Bissell
Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg and Mina J. Bissell
Part of Vienna Series in Theoretical Biology
Part of Vienna Series in Theoretical Biology
Category: Science & Technology | Wellness
Category: Science & Technology | Wellness
-
$60.00
Apr 27, 2021 | ISBN 9780262045216
-
Apr 27, 2021 | ISBN 9780262362085
YOU MAY ALSO LIKE
The Complete Idiot’s Guide to String Theory
Verbal Workout for the GMAT, 4th EditionÂ
Environmental Science
Table Of Contents
Series Foreword ix
Preface xi
1 Introduction and Overview 1
I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11
2 The Search for Progress and a New Theory Framework in Cancer Research 13
3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41
II THE SYSTEMS DIMENSION OF CANCER 61
4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63
5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129
6 Adaptation of Molecular Interaction Networks in Cancer Cells 141
7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163
III THE TIME DIMENSION OF CANCER 185
8 Darwinism, Not Mutationalism, for New Cancer Therapies 187
9 Cancer as a Reversion to an Ancestral Phenotype 205
10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227
IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245
11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247
12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271
13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299
14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323
15 Niche Reconstruction to Revert or Transcend the Cancer State 353
V WHAT NEXT? 391
Contributors 397
Index 399
21 Books You’ve Been Meaning to Read
Just for joining you’ll get personalized recommendations on your dashboard daily and features only for members.
Find Out More Join Now Sign In